Computational challenges of single cell profiling

Goal today

• What is single cell sequencing?

• How does it help

• Discuss the major computational challenges associated with single cell sequencing.

• Short talk about a current project from my lab where we profile Candida albicans at the single cell level.

Information loss in bulk profiling

scDNA-seq and tumoral evolution

• Eleven grand challenges in single-cell data science

Single cell in the fungal world

• Candida albicans single cell project (my lab)

BIOL 480

© M Hallett, 2020 Concordia University